1,457 HEADLINES from 8/2006 to 12/2004

OUR TERMS & CONDITIONS OF USE... The MS News Channel

2006-09-14T23:59:00.000-07:00

2006-09-14T23:17:00.000-07:00

WE HAVE TAKEN THE 432 HEADLINES FROM JUNE 2006, JULY 2006, AUGUST 2006 AND PART OF SEPTEMBER FROM OUR MS HOME PAGE AND ARE IN THE PROCESS OF TRANSFERING THEM TO THIS ARCHIVE

PLEASE PARDON OUR CONSTRUCTION....THIS NEW ARCHIVE PAGE WITH IT'S 1,365 HEADLINES WAS JUST COMPLETED 2 DAYS AGO

1,384 HEADLINES ARE BELOW:

2006-09-11T23:59:00.001-07:00

OUR ARCHIVES ARE BELOW:

2006-09-11T23:59:00.000-07:00

2006-09-11T19:49:00.000-07:00

Opexa begins trading on NASDAQNEW MS DRUGS:
"Opexa -- formerly called PharmaFrontiers -- has exclusive license from Houston's Baylor College of Medicine for individualized cell therapies and has initiated a Phase IIb clinical trial to evaluate effectiveness in treating MS.

Opexa also holds the exclusive worldwide license from the University of Chicago, through a relationship with Argonne National Laboratory, for patents relating to the use of adult pluripotent stem cells derived from patients' own circulating blood...."

2006-09-03T15:38:00.000-07:00

Engineered Immune Cells Beat Back Cancer

Engineered Immune Cells Beat Back Cancer...Scientific American
"....Now scientists have transformed immune cells into cancer fighters outside the body--and prompted complete remission in two subjects when those cells were reintroduced.

Immune cells such as lymphocytes, also known as T cells and pictured in blue above, recognize health threats via special receptors on the cell surface. Steven Rosenberg of the National Cancer Institute and his colleagues first cloned the genes governing the cancer-recognizing receptor in immune cells from a patient who had successfully beaten back melanoma....... "

2006-09-02T15:37:00.000-07:00

MS Bike Tour

PERSEVERANCE=A Real Hero: Lauren Zaccaro...working on a NASA project: "...Young, attractive, fit and a successful engineer, Lauren Zaccaro hardly fits the typical description of a woman living with chronic illness. The five-foot, seven-inch blonde looks more like a competitive athlete.... 'Although initially I was somewhat shocked at the diagnosis, I'm thankful that I'm not facing something even worse,' said Zaccaro, who is currently working on a NASA project to remove water and carbon dioxide from the air while maintaining proper cabin pressure and temperature for astronauts in space on a future space vehicle. 'I feel fortunate. The effects of multiple sclerosis aren't keeping me from pursuing my dreams or keeping me from enjoying my favorite activities......'"

2006-09-02T15:35:00.000-07:00

’A Million Reasons’ to fight for the disabled:

PERSEVERANCE=Real Heros:
Author Alan Labonte is celebrating the release of his new book, "A Million Reasons." Labonte was diagnosed with MS in 1991 and subsequently fired from his job [CLICK FOR MORE]:
NEW BOOK...."Alan Labonte lives a good life. He has a nice home on Border Street, a loving wife, Lora, and a good job as a member of the faculty at Boston University. But there was a time not too long ago when Labonte found it a struggle to keep a positive outlook on life. After relocating his family to Cohasset from the western part of the state to take on a new job at the law firm of Hutchins & Wheeler, doctors informed him he had contracted MS. He was fired from his job just six months later.

Today, he is happy to be able to share his story with others, through his newly released book, 'A Million Reasons,' published by Cohasset-based publishers Hot House Press.

Labonte is able to share his story with others for one reason: he turned down a $3 million settlement offered by Hutchins & Wheeler. By accepting, he would have also been agreeing to a non-disclosure clause, which would have prevented him from telling his story. Instead, he chose to take a risk and follow his case through the legal system. 'Im sure they couldnt believe it,' said Labonte about turning down the money....."

2006-09-02T15:33:00.000-07:00

MS in Focus Magazine

FREE DOWNLOAD: MS in Focus Magazine [available in English, Spanish]
"Issue 8 - Genetics and hereditary aspects of MS.....This issue of MS in focus features articles from the world's most renowned MS genetic scientists, who provide a complete picture of what we know about MS and genetics and what the future holds in this field. Articles comprehensively outline why genetics is important when researching MS, how knowledge about the genetics of MS is being gathered around the world, what remains to be learned, and what this knowledge means to people with MS and their families"

Montel Williams

2006-09-02T15:31:00.000-07:00

Today Montel will meet people who share his personal battle with MS

"Montel Williams: Today Montel will meet people who share his personal battle with MS.

2006-09-02T15:30:00.000-07:00

"Alecia Harris: Multiple Sclerosis Will Not Defeat Me":

PERSEVERANCE=Real Heros: "Alecia Harris is a fighter and will continue to fight as long as MS is her opponent.
Diagnosed with MS in 2001 at the height of her career, Harris changed career paths and made it her point to spread the word about MS and getting tested early.....

Entrez PubMed

2006-09-02T15:29:00.000-07:00

"Patient information on cognitive symptoms in multiple sclerosis - acceptability in relation to disease duration.":

Patient information on cognitive symptoms in MS - acceptability in relation to disease duration
[Abstract: National Library of Medicine]
".....Conclusion - Information on cognitive deficits does not increase fears even in recently diagnosed MS patients. Patients with perceived deficits found the information more relevant than others and also less familiar. Thus, it seems appropriate to offer information about cognitive impairments to MS patients."

2006-09-02T15:28:00.000-07:00

"Loss of interhemispheric inhibition in patients with multiple sclerosis is related to corpus callosum atrophy.":

Loss of interhemispheric inhibition in patients with MS is related to corpus callosum atrophy
[Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.]
"....Interhemispheric physiological inhibition thus is impaired in patients with MS, potentially contributing to impairment of motor control. This work suggests one way in which FMRI monitoring of the transcallosal interactions in motor cortex could become a tool for evaluation of therapies that may enhance function in reversibly impaired pathways.

2006-09-02T15:26:00.000-07:00

MRI findings in benign multiple sclerosis are variable

MRI findings in benign multiple sclerosis are variable - Dept. of Neurology, Mayo Clinic,
[Abstract: Pub Med]

2006-09-02T15:25:00.000-07:00

Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response:

Innate Immunity in MS: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response
[Karni et al. 177 (6): 4196 -- The Journal of Immunology]
"......These results demonstrate abnormalities of DCs in MS and may explain the immunologic basis for the different stages and clinical patterns of MS."

2006-09-02T15:24:00.000-07:00

Prognostic Factors for Early Severity in a Childhood Multiple Sclerosis Cohort:

Prognostic Factors for Early Severity in a Childhood MS Cohort
[Mikaeloff et al. 118 (3): 1133 -- Pediatrics]
".....CONCLUSIONS. The clinical and MRI prognostic factors for early severity that were identified were used as the basis of a predictive tool, which will be validated in another cohort. This tool should make it possible to identify subgroups at risk of early severe disease and should facilitate therapeutic studies"

2006-09-02T15:23:00.000-07:00

Heterogeneity at the HLA-DRB1 locus and risk for MS:

".....These results contribute substantially to our understanding of the DRB1 locus and MS, and underscore the importance of using large sample sizes to detect modest genetic effects, particularly in studies of genotype–phenotype relationships."

2006-09-02T15:20:00.000-07:00

10 VITAL SIGNS YOUR DOCTOR MIGHT MISS:

10 VITAL SIGNS YOUR DOCTOR MIGHT MISS ]MS is one of the 10
"SOME MEDICAL CONDITIONS CAN BE MISDIAGNOSED OR COMPLETELY MISSED, SO IT'S VITAL TO KNOW ABOUT MORE UNUSUAL SYMPTOMS...."

Atlas of MS Database

2006-09-02T15:16:00.000-07:00

CLICK

Atlas of MS Database [click for more]
The Multiple Sclerosis International Federation (MSIF) has launched the Atlas of MS a searchable database of information on the epidemiology of multiple sclerosis – who gets MS – as well as treatment access and resources available to people with MS within a particular country, region, or worldwide. There is no charge to use the Atlas.

Data are organized into six categories: epidemiology, services and support, diagnosis, management, treatment, and quality of life. Users can choose a category and region to search for available information. For example, popular queries are: What is the number of MRI machines in Europe? What is the global availability of travel insurance for people with MS? How many hospital-based interdisciplinary teams are available for people with MS in South America?

The value of the Atlas, states the MSIF, “is in replacing impressions and opinions with facts and figures.” The data in the Atlas of MS was compiled by the MSIF and the World Health Organization through a survey of MS-related associations, including member societies of the MSIF such as the National MS Society (USA). Information will be added as it becomes available, and the whole database will be updated every four years. This is a valuable resource for anyone interested in many aspects of multiple sclerosis.

"The young person's guide to MS"

2006-09-01T15:12:00.000-07:00

CLICK:

NEW BOOK: "The young person's guide to MS provides information to 10-15 year olds with a parent with MS
The book was written by Kerry Mutch, an MS specialist nurse in Liverpool, who says: 'It can be very lonely for teenagers who have a parent with MS. One of the aims of the book is to help young people explore their feelings about MS and how it affects them, as well as making them realise that they are not alone in the feelings that they may be experiencing at this challenging time of their lives.' This book has been produced with the help of young people who know what it is like to have a parent with MS and who share their experiences, worries and emotions about living with MS in their family....It is split into two sections....."

Two complementary brain scans can pick up Alzheimer's before it happens

2006-09-01T14:56:00.000-07:00

CLICK HERE TO READ FULL STORY: "Alzheimer's PredictorTwo complementary brain scans can pick up Alzheimer's before it happens.By Brad KlozaSeptember 19, 2006 | Mind & Brain

"Whether it's misplacing your keys or forgetting a phone number, lots of people wonder when simple lapses in memory might be an early sign of Alzheimer's. Now researchers are working on software that might help predict who's really at risk.

New York University brain researchers Susan De Santi and Lisa Mosconi are part of a team developing software that they say will help tell the difference between a person who's just getting old and one who's on the road to Alzheimer's. The software combines information from two different types of brain scans: MRI and PET.

The software takes advantage of the strengths of these two types of brain scans, and each helps mitigate areas where the other is weak. MRI, for instance, is a very good tool to study the inner makeup of the brain and to pinpoint precise locations. PET is much less precise, but does a good job of showing where the brain is using sugar, the energy source of living cells. Plunges in energy use could signal decline in brain function, and the researchers decided to focus on the hippocampus, a part of the brain known to be affected in Alzheimer's.

"What we are trying to do is to find a measure that would predict decline from normal aging to Alzheimer's disease," says Mosconi. "And it looks like the hippocampus is particularly involved in early Alzheimer's disease..."

New MS drug on licensing fast track

2006-09-01T14:49:00.000-07:00

CLICK:(Liverpool) Tysabri...New MS drug on licensing fast track [CLICK for Full Article]
A NEW drug to treat multiple sclerosis has been accepted for a fast-track assessment process by the Government's health watchdog "New MS drug on licensing fast track"

Drug Insight: using statins to treat neuroinflammatory disease:

2006-09-01T13:36:00.000-07:00

CLICK
[MS Weber-postdoctoral fellow at the University of California San Francisco (UCSF)
".... Statins can prevent and even reverse ongoing paralysis in experimental autoimmune encephalomyelitis-the mouse model for multiple sclerosis-and on the basis of these findings, statins are now being tested in patients with multiple sclerosis in clinical trials."

Immunopathogenesis and immunotherapy of MS

2006-09-01T13:33:00.000-07:00

CLICK
"....Here, we review current knowledge of the immunopathogenesis of MS and corresponding animal models of disease, and discuss new immunointerventional treatment strategies based on changing pathogenetic concepts..."

Engineered Immune Cells Beat Back Cancer

2006-09-01T13:18:00.000-07:00

CLICK HERE "....Now scientists have transformed immune cells into cancer fighters outside the body--and prompted complete remission in two subjects when those cells were reintroduced.

Immune cells such as lymphocytes, also known as T cells and pictured in blue above, recognize health threats via special receptors on the cell surface. Steven Rosenberg of the National Cancer Institute and his colleagues first cloned the genes governing the cancer-recognizing receptor in immune cells from a patient who had successfully beaten back melanoma....... "

DRUG IN THE PIPELINE FOR MS: Daclizumab for the treatment of MS

2006-08-31T14:46:00.000-07:00

href="http://memphis.bizjournals.com/sanfrancisco/stories/2006/02/27/focus8.html">CLICKNEW DRUG IN THE PIPELINE FOR MS: Daclizumab for the treatment of MS:
"It's easy to understand the $800 million alliance forged between PDL Biopharma and Biogen Idec in August. The deal answers Biogen's pipeline needs and provides PDL a kindred biotech with experience in MS and cancer...The deal calls for PDL and Biogen to jointly develop, manufacture and sell three antibody products in mid-stage clinical trials. This includes PDL's drug Daclizumab for the treatment of MS......"

Scientists warn of 'unproven stem cell treatments'

2006-08-31T14:43:00.000-07:00

CLICK: "Scientists warn of 'unproven stem cell treatments'"

MS: Scientists warn that some stem cell treatments could kill:
"A group of leading British scientists warned patients today to be wary of 'extravagant' claims made for 'unorthodox' stem cell treatments offered abroad....."In the case of these unorthodox 'stem-cell' treatments, the protocols and results have not been published or subject to independent review.

"Although scientists are making great strides in stem-cell science, there is no published evidence to support claims that stem cells can safely repair tissue damage caused by MS. "Indeed, there is concern that these unproven treatments could be dangerous, potentially exposing patients to the risk of uncontrolled and inappropriate tissue generation."...."

Genentech and Biogen Idec Announce Positive Results From a Phase 2 Trial of Rituxan in Relapsing-Remitting Multiple Sclerosis

2006-08-31T14:39:00.000-07:00

CLICK: "Genentech and Biogen Idec Announce Positive Results From a Phase 2 Trial of Rituxan in Relapsing-Remitting Multiple Sclerosis"

Genentech and Biogen Idec Announce Positive Results From a Phase 2 Trial of Rituxan in Relapsing-Remitting Ms
"Genentech, Inc. and Biogen Idec, Inc. announced today that a phase 2 study of Rituxan(R) (Rituximab) for relapsing-remitting multiple sclerosis (RRMS) met its primary endpoint. The study of 104 patients showed a statistically significant reduction in the total number of gadolinium enhancing T1 lesions observed on serial MRI scans of the brain at weeks 12, 16, 20, and 24 in the Rituxan-treated group compared to placebo. Genentech and Biogen Idec will continue to analyze the study results and will submit the data for presentation at an upcoming medical meeting.

This phase 2 randomized, double-blind, parallel-group, placebo-controlled, multi-center study was designed to evaluate safety and efficacy of Rituxan in adults with RRMS. A total of 104 patients at 48 sites in the U.S. and Canada were randomized to receive either a single treatment course of Rituxan or placebo. Gadolinium-enhancing lesions visible by MRI scans were assessed at 12, 16, 20 and 24 weeks. Patients will continue to be followed for 48 weeks.

"These initial results exceeded our expectations," said Hal Barron, MD, Genentech senior vice president, development and chief medical officer. "Showing a significant benefit at 24 weeks in this small phase 2 trial supports our hypothesis that selective B-cell targeted therapy may play an important role in the treatment of MS."

Jeremy's Juggernauts' do battle with MS

2006-08-31T14:36:00.000-07:00

CLICK
‘Jeremy's Juggernauts' do battle with MS: "As long as researchers keep working on a cure for MS, the Kohlers of Barnhart plan to continue to take part in fund-raising events to battle the disease......"

Disproving the myths of disability

2006-08-29T14:33:00.000-07:00

CLICK

MS: Disproving the myths of disability - Mayo Clinic
"....The power of positive thinking.....Your attitude toward yourself is reflected back to you from those around you,' Holtackers says. 'Every day, challenge yourself to deal positively with negative circumstances. When you project a positive attitude, those around you tend to become more positive, too.....'"

"Roles of immunoglobulins and B cells in multiple sclerosis: From pathogenesis to treatment."

2006-08-29T14:31:00.000-07:00

CLICK:

"Roles of immunoglobulins and B cells in MS: From pathogenesis to treatment":
[Abstract: Pub Med]

"Risk factors for falling among people aged 45 to 90 years with multiple sclerosis"

2006-08-29T14:29:00.000-07:00

CLICK:

Risk factors for falling among people aged 45 to 90 years with MS:
[Department of Occupational Therapy, University of Illinois]
"CONCLUSIONS: There are a number of factors associated with an increased risk of falling among people aging with MS that are amenable to intervention and therefore warrant the attention of health care providers serving that population."

Questionnaire in a heterogeneous group of MS patients

2006-08-29T14:27:00.000-07:00

CLICK

Utility of the National Eye Institute VFQ-25 Questionnaire in a Heterogeneous Group of Multiple Sclerosis Patients:
[Abstract: National Library of Medicine]
"CONCLUSIONS: The VFQ-25 questionnaire is a sensitive and useful tool in assessing visual function in MS patients. Such patients have quality of life indices similar to glaucoma and cataract patients, underscoring the significance of visual symptoms in MS."

New Hope For MS Patients

2006-08-29T14:25:00.000-07:00

CLICK
NBC VIDEO: "New Hope For MS Patients"..[CLICK TO WATCH
"Recent studies suggest exercise, like chair aerobics, can help patients with MS regain balance and strength. So, they're pairing MS with physical therapists and fitness trainers...Joanna Lee believes she's proof that exercise helps. Lee says her MS symptoms have improved, since joining exercise classes ..."I'm not tired. I feel like I'm more flexible. I still feel tight and stiff, but it's more flexible," said Lee.

'Invisible' Brain Changes May Be Key to MS Progression

2006-08-29T14:23:00.000-07:00

CLICK
'Invisible' Brain Changes May Be Key to MS Progression - Yahoo! News: "New research suggests that subtle, undetected changes in brain tissue affect disease progression for people with MS...."

Millennium Announces Phase I Trial of MLN0415 for Inflammatory Disorders

2006-08-29T14:15:00.000-07:00

CLICK
Millennium Announces Phase I Trial of MLN0415 for MS:
"Millennium Pharmaceuticals, Inc. today announced the initiation of a Phase
I study of MLN0415, an oral, highly selective, small molecule inhibitor of
IKK2, which targets a major inflammatory pathway...."

I Was Betrayed By Stem Cell Claims

2006-08-29T14:13:00.000-07:00

CLICK
"I Was Betrayed By Stem Cell Claims":
A MS patient yesterday warned fellow patients against a UK-registered company which promised to treat him with "pioneering" stem cell treatment. Malcolm Pear handed over pounds 14,000 after reading testimonials on the Advanced Cell Therapeutics (ACT) website, which claims it can reduce the symptoms of a range of diseases from MS and Parkinson's to HIV.

Moments after undergoing the procedure in Europe, Malcolm Pear, 51, says he was able to walk unaided, despite having to previously rely on elbow crutches to move.

After returning to the UK, his wife Lesley spent hours on the phone promoting the treatment to hundreds of callers who inquired about its benefits.

But three months after stem cells from discarded umbilical cords were injected into his spine, the health of the former Bromsgrove chartered accountant deteriorated sharply. The Pears then found it impossible to contact ACT and the only correspondence they received were emails offering expensive top-up treatments....

Ruby's Rap

2006-08-29T14:12:00.000-07:00

CLICK
Teri Garr talks about everything from her leaking roof to her fight to educate people that MS doesn't mean wheelchairs anymore!

Ride of a Lifetime: Life's Pleasures

2006-08-29T14:09:00.000-07:00

CLICK

PERSEVERANCE=Real Heros: Christin Harding's Ride of a Lifetime: Life's Pleasures: "This is a story of dedication above all else. Christin Harding was diagnosed with MS 13 years ago. T was Christin's catalyst to live each day like it was her last. She says, in a way, this disease was a blessing in disguise....13 years later, there's still no wheelchair...."

Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in MS

2006-08-29T14:08:00.000-07:00

CLICK

Marijuana as medicine: Consider the pros and cons

2006-08-29T14:06:00.000-07:00

CLICK
"MAYO CLINIC: Marijuana as medicine: Consider the pros and cons"
"Whether marijuana will relieve your side effects or symptoms is questionable. But the risks of smoking pot are clear. Examine the facts about marijuana before making your decision

People have used marijuana as a medical treatment for thousands of years. Such uses extend even to modern America. Marijuana was listed by the U.S. Pharmacopeia, the organization that sets quality standards for approved drugs in the United States, until the 1940s, when political pressure against marijuana's recreational use triggered its removal.

Despite the U.S. Supreme Court's ruling that state laws allowing medicinal use of marijuana must bow to federal law banning it, proponents still tout this controversial plant's ability to treat pain, nausea and other uncomfortable side effects of medical treatment as well as some disease symptoms.

Marijuana 101: The plant and its components-----
Marijuana refers to the dried flowers, leaves, stems and seeds of the Cannabis sativa plant. These parts contain the compounds that produce the mind-altering effect that recreational users seek when smoking or ingesting the plant — but they also provide components with potential medical benefits.

Marijuana contains at least 60 chemicals called cannabinoids. Researchers are evaluating how effective some of these cannabinoids might be in controlling symptoms of certain medical conditions. For example:

THC....An abbreviation for delta-9-tetrahydrocannabinol, THC is the main component responsible for marijuana's mind-altering effect. It also may help treat signs and symptoms such as nausea and vomiting that are associated with a number of medical conditions.

Cannabinol and cannabidiol....These compounds have some of the properties of THC, but cause less psychoactive effects — the high.

Dronabinol (Marinol)....Dronabinol (dro-NAB-in-ol) is a man-made version of THC available by prescription. It's used to prevent nausea and vomiting after cancer chemotherapy when other medicines for these side effects don't work, and to increase appetite in people with AIDS.

How it works-----
When smoked or ingested, THC and other cannabinoids in marijuana attach to two types of receptors on cells in your body — like keys in a lock — affecting the cells, once attached.

CB1 is one such receptor. CB1 receptors are found mainly in your brain, especially in areas that control body movement, memory and vomiting. This helps explain why marijuana use affects balance and coordination and impairs short-term memory and learning, and why it can be useful in treating nausea, pain and loss of appetite.

The other type of receptor, CB2, is found in small numbers elsewhere in your body, mainly in tissue of the immune system, such as your spleen and lymph nodes. The function of these receptors is not well understood. They may serve as brakes on immune system function, which may help explain why marijuana suppresses your immune system.

After you smoke marijuana, its ingredients reach their peak levels in your body within minutes, and effects can last up to an hour and a half. When eaten — the plant is sometimes mixed with food — the ingredients can take several hours to reach their peak levels in your body, and their effects may last for hours.

The prescription drug dronabinol, which is taken as an oral capsule, takes effect in about 30 minutes and can continue to stimulate appetite for more than a day.

Possible medical uses----
Scientists studying marijuana's potential medical uses have found that it may help treat a variety of conditions.

Nausea----
One of THC's medical uses best supported by research is the treatment of nausea. It can improve mild to moderate nausea caused by cancer chemotherapy and help reduce nausea and weight loss in people with AIDS.

Younger people may find marijuana more useful as a treatment for nausea than do older people — who may not tolerate its mind-altering side effects ..."

Profile of a newsmaker Doctor to ride for employee at MS 150 tour

2006-08-29T14:03:00.000-07:00

CLICK
Profile of a newsmaker Doctor to ride for employee at MS 150 tour

Multiple sclerosis damage found in 'normal' brain tissue

2006-08-29T14:02:00.000-07:00

CLICK
Multiple sclerosis damage found in 'normal' brain tissue: "
The effects of multiple sclerosis (MS) extend beyond visibly affected areas into large portions of the brain that outwardly appear normal, according to a study appearing in the September issue of Radiology......"

Side Effect Considerations with Disease-Modifying Therapies

2006-08-29T14:00:00.000-07:00

CLICK
"Experts Speak Out - Side Effect Considerations with Disease-Modifying Therapies" [CONTINUING EDUCATION-Interactive Flash Program for Medical Professionals]
Purpose...To review the latest information on the side effects associated with the available disease-modifying therapies (DMTs) used to treat relapsing-remitting multiple sclerosis (RRMS) and to offer strategies for their management.

10 Questions for Meredith Vieira

2006-08-28T13:58:00.000-07:00

CLICK
10 Questions for Meredith Vieira :
"....On Sept. 13 the veteran journalist and mother of three takes a seat opposite Matt Lauer as the new co-anchor of NBC's Today show. She talked with TIME's Jeff Chu about how her husband's battles with cancer and MS have changed her, ..."

National MS Society | Teen InsideMS

2006-08-28T13:55:00.000-07:00

CLICK
Teen InsideMS - Online version or PDF

Interferon treatment may trigger primary headaches in multiple sclerosis patients

2006-08-28T13:54:00.000-07:00

CLICK
Interferon treatment may trigger primary headaches in MS patients
[Abstract-MS Center, C. Besta National Neurological Institute, Milan,, Italy]
"....Worsening of pre-existing headaches or development of de novo headache occurred only in the interferon-group (41 and 48%, respectively) and not in the other group (P<0.001). These results show that headache should be considered among the side-effects of interferon in MS patients."

Genentech, Biogen say cancer drug helps against MS

2006-08-28T13:52:00.000-07:00

CLICK
Genentech, Biogen say cancer drug helps against MS:
"Biotechnology companies Genentech Inc. and Biogen Idec Inc. on Monday said their cancer drug Rituxan showed hints of effectiveness against MS in a small mid-stage trial. "These initial results exceeded our expectations," Hal Barron, Genentech's chief medical officer, said in a statement.

The study involved 104 adults in the United States and Canada with the most common form of multiple sclerosis, in which flare-ups of symptoms are followed by full or partial recovery between attacks. They were given either a single treatment course of Rituxan, or a placebo.

It showed a statistically significant reduction among those given Rituxan in the total number of brain lesions seen on MRI scans at weeks 12, 16, 20 and 24, compared with those receiving placebo.

Rituxan, an antibody which is one of the biggest-selling treatments against non-Hodgkin's lymphoma, works by blocking immune-system B cells.

"Showing a significant benefit at 24 weeks in this small Phase II trial supports our hypothesis that selective B-cell targeted therapy may play an important role in the treatment of MS."

Rates of side effects were comparable in those taking Rituxan and those taking placebos, the companies said...."

Bell battles to raise awareness of MS

2006-08-28T13:50:00.000-07:00

CLICK
PERSEVERANCE=Real Heros: Despite having Multiple Sclerosis, Jacob Bell is still able to play with his two-year-old daughter, Mackenzie....click for full article
Bell is an MS Ambassador, and is doing what he can to raise awareness of the disease...

The Celebrity Clean House Bazaar: Where the stars shine down on MS patients

2006-08-28T13:45:00.000-07:00

The Manila Times Internet Edition | WEEKEND >CLICK

"...In the Philippines, an estimated 8,400 suffer from the disease. Small number, considering that 300,000 people are affected by MS in the United States alone, and even more in Europe.....celebrities in entertainment, television, sports, journalism and public service came together on August 16 to raise funds for the MS Society by selling some of their possessions in a bazaar. Dubbed “Celebrity Clean House,”....."

Family focuses on fitness, giving back

2006-08-28T13:43:00.000-07:00

CLICKFamily focuses on fitness, giving back

PERSEVERANCE=Real Heros: MS doesn’t slow Liz Hanser - girls’ coach

2006-08-28T13:41:00.000-07:00

CLICKPERSEVERANCE=Real Heros: MS doesn’t slow Liz Hanser - girls’ coach

MRI changes in relapsing-remitting MS patients complaining of fatigue after IFNbeta-1a injection

2006-08-26T13:21:00.000-07:00

CLICK

Hum Brain Mapp. 2006 Aug 24; [Epub ahead of print]...[Abstract: National Center for Biotechnology Information]
"If fatigue in multiple sclerosis (MS) is related to an abnormal activation of the sensorimotor brain network, the activity of such a network should vary with varying fatigue. We studied 22 patients treated with interferon beta 1a (IFNbeta-1a; Avonex, Biogen....

2006-08-18T16:05:00.000-07:00

MS Society honorees are true champs:

"it's no wonder that the National Multiple Sclerosis Society wanted to honor Brad Alford and Dr. John Forestner at its annual Dinner of Champions fundraising even...":

2006-08-18T16:03:00.000-07:00

"MS Harborfest hopes to raise $130K":

2006-08-17T16:47:00.000-07:00

"MS Tour for Cure rolls again in October":

New Orleans MS Tour for Cure rolls again after being cancelled last year due to Hurricane Katrina
The ride has had as many as 1,800 cyclists and has raised as much as $800,000 for the Louisiana MS Chapter.....

2006-08-17T16:33:00.000-07:00

"Hacker' putts in thousands to benefit MS chapter's work":

2006-08-17T16:25:00.000-07:00

Trial Results Published in Neurology Show Risk of Developing Multiple Sclerosis Significantly Reduced with Interferon Beta-1b Early Treatment:

2006-08-17T16:23:00.000-07:00

Caraco gets FDA OK for generic multiple sclerosis drug:

Pharmaceutical Business Review: "The FDA has granted final approval for Caraco Pharmaceutical's baclofen tablets, the company's generic version of Novartis' Lioresal, a muscle relaxant used for the alleviation of signs and symptoms of spasticity resulting from MS..."

2006-08-17T16:02:00.000-07:00

Schering says drug helps fight MS:

German drug maker Schering said in a statement on Thursday research showed that its key drug works in tackling MS. The study, published in medical journal Neurology, shows that the group's drug Betaseron, if taken early, can cut the chances of the disease developing by half. It also shows that the drug doubled a patient's chances of avoiding the disease developing compared to patients in the study who only took a placebo....."

2006-08-17T16:01:00.000-07:00

Caregiver fleeces three clients:

"A Jackson woman who was a caregiver for three women with MS ended up being more of a taker. Kerri Lynn Clark, 20, was sentenced Wednesday to 90 days in jail. She pleaded guilty to using a credit card without consent....."

2006-08-17T15:57:00.000-07:00

Trial Results Published in Neurology Show Risk of Developing Multiple Sclerosis Significantly Reduced with Interferon Beta-1b Early Treatment

BETASERON: Trial Results Published in Neurology Show Risk of Developing Multiple Sclerosis Significantly Reduced with Interferon Beta-1b Early Treatment
"Researchers have found that treatment of patients with interferon beta-1b after a first attack suggestive of MS cuts their risk of developing the disease in half over the next two years, according to results from the BENEFIT (BEtaferon(R)/BEtaseron(R) in Newly Emerging MS for Initial Treatment) clinical trial.....

2006-08-16T15:58:00.000-07:00

Tysabri Recovery Plan:

Tysabri Recovery Plan
"....In an interview with this magazine last year, the late Donal Geaney wouldn't comment on Elan except to say how proud he was of what it had achieved. Having just settled an unfair dismissal case with his former employers, raking up old roots didn't interest him. Geaney had stood down from Elan three years previously, following a crash in the company's share price....."

2006-08-12T14:31:00.000-07:00

Immunopathogenesis and immunotherapy of MS

Nat Clin Pract Neurol. 2006
"....Here, we review current knowledge of the immunopathogenesis of MS and corresponding animal models of disease, and discuss new immunointerventional treatment strategies based on changing pathogenetic concepts..."

2006-08-12T14:30:00.000-07:00

MRI changes in relapsing-remitting MS patients complaining of fatigue after IFNbeta-1a injection
Hum Brain Mapp. 2006 Aug 24; [Epub ahead of print]...[Abstract: National Center for Biotechnology Information]
"If fatigue in multiple sclerosis (MS) is related to an abnormal activation of the sensorimotor brain network, the activity of such a network should vary with varying fatigue. We studied 22 patients treated with interferon beta 1a (IFNbeta-1a; Avonex, Biogen....

2006-08-12T14:17:00.000-07:00

"Denver's shining stars for MS are the real thing":...[CLICK HERE]

2006-08-01T14:37:00.000-07:00

The Manila Times Internet Edition | WEEKEND > The Celebrity Clean House Bazaar: Where the stars shine down on MS patients

"...In the Philippines, an estimated 8,400 suffer from the disease. Small number, considering that 300,000 people are affected by MS in the United States alone, and even more in Europe.....celebrities in entertainment, television, sports, journalism and public service came together on August 16 to raise funds for the MS Society by selling some of their possessions in a bazaar. Dubbed “Celebrity Clean House,”....."

2006-05-31T08:44:00.000-07:00

Botox Soothes Overactive Bladder
[ABSTRACT: CME Teaching Brief - MedPage Today]
"....Botox (botulinum toxin type A) injected directly into the bladder's detrusor muscle at 30 different sites not only tamed an overactive organ but kept the bladder calm for almost a year, according to Swiss researchers.

Unlike Botox treatments in other muscular disorders or for cosmetic repair, where injections must be repeated at frequent intervals, one injection could provide a long-term cure, Daniel Schmid Jr., M.D., of the University of Zurich reported at the American Urological Association meeting here.

"We were very surprised that we didn't have to re-inject these people after three months or six months," Dr. Schmid said.

Nine months after the initial treatment, 82% of 150 patients, refractory to anticholinergics, who were treated with Botox, were continent, a statistically significant improvement (P<.001 level), Dr. Schmid said. "We can now say that the mean effectiveness of one series of injections is 11 months," he added....At 11 months, 43% of the patients did not require any further treatment, while 23% of the patients have required re-injections. Thirty-one percent of patients have been able to control the return of urgency with anticholinergic drugs...."

2006-05-30T13:47:00.000-07:00

Harvard Medical: The Skinny on Fat
"It’s especially easy these days to feel that the gurus of health don’t know what they’re talking about. What else would explain the recent results from the large, 8-year-long Women’s Health Initiative study showing that a low fat diet—long a mainstay of government healthy eating recommendations—does almost nothing to reduce the risk of heart disease, stroke, breast cancer, or colon cancer?....."

2006-05-30T09:10:00.000-07:00

ORAL MS MEDS: Biogen Idec To Acquire Fumapharm AG: "...'This acquisition supports our goal of developing innovative therapeutic options for people living with MS,' said James C. Mullen, Biogen Idec's president and chief executive officer. 'We look forward to continuing the development of BG-12, a promising oral compound in MS...."

2006-05-29T23:57:00.000-07:00

OUR NEW WEBSITE: "TYSABRI NEWS"....click here

2006-05-29T20:11:00.000-07:00

Elan says aims for clarity on Tysabri by June 28
"Speaking at the group's annual general meeting in Dublin, Chief Executive Kelly Martin said he hoped that the group would have more of an idea of the drug's future prospects by June 28."

2006-05-29T19:48:00.000-07:00

Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouse
[Abstract: Wiley InterScience: Journal]
Journal of Neuroscience Research
Volume 83, Issue 8, Date: June 2006, Pages: 1533-1539

2006-05-29T19:45:00.000-07:00

Balance and gait improved in patients with MS after physiotherapy based on the Bobath concept:
[Abstract: Wiley InterScience: Journal] "Conclusion: The findings indicate that balance and gait can be improved after physiotherapy based on the Bobath concept, but this should be further evaluated in larger controlled trials of patients with MS "

2006-05-29T19:32:00.000-07:00

Natalizumab and progressive multifocal leukoencephalopathy: migrating towards safe adhesion molecule therapy in MS
[Abstract: Doctors Guide]
"This review examines how the inhibition of alpha4beta1-mediated adhesion might establish a unique milieu for the development of PML and how future approaches to selective adhesion molecule therapy in multiple sclerosis might avoid a similar fate."

2006-05-27T11:22:00.000-07:00

Plasma cerebrosterol and magnetic resonance imaging measures in MS
[Abstract: National Institutes of Health]..."RESULTS: By multiple-regression analysis, we uncovered negative correlations between the cerebrosterol-cholesterol ratio in plasma and both age at sampling (beta=-0.35 and p=0.079 in RRMS; beta=-0.76 and p=0.006 in PPMS) and volume of T(2)-weighted lesions (beta=-0.52 and p=0.078 in RRMS; beta=-0.50 and p=0.247 in PPMS). CONCLUSION: We hypothesize that decreases in plasma cerebrosterol may reflect the total spatiotemporal burden of MS-the cumulative effects of its dissemination in space and its duration in time"

2006-05-27T11:17:00.000-07:00

Marina to host MS fishing tourney in June:
GOOD IDEA FOR OTHER CITIES:"Port Clinton, will host the 17th annual Multiple Sclerosis Fishing Tournament Wednesday, June 14, with more than 100 men and women participating."

2006-05-27T11:16:00.000-07:00

"Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed MS patients.

2006-05-27T11:06:00.000-07:00

"Very early treatment of multiple sclerosis (MS) -- before doctors have even confirmed their diagnosis of the nerve disease -- can significantly delay its progression, a Canadian-led study shows":
" Usually, doctors don't start treatment until a person has had two separate attacks, but Dr. Mark Freedman of the University of Ottawa and his colleagues found they could delay the development of the disease by starting people on a drug called interferon beta-1b (brand name Betaseron) after just one episode of symptoms suggestive of MS. Freedman describes the treatment benefits as 'remarkable.' The study involved 468 people who'd had just one MS-like attack, as well as at least two areas of nerve damage visible on a brain scan."

2006-05-27T08:01:00.000-07:00

HERO'S = PERSEVERANCE: Golf a lifeline in battle with MS - Tony Johnstone is a Senior PGA Championship player:

2006-05-27T07:38:00.000-07:00

HERO'S = PERSEVERANCE: MS won't bench Chris Kieser

2006-05-27T07:30:00.000-07:00

Cytokine-Suppressor Gene Protects Mice From MS-Type Damage:
[Abstract: Journal of Neuroimmunology] "The expression of a gene, known as suppressor of cytokine signaling 1 gene (SOCS1), protects oligodendrocytes from the deleterious effects of interferon gamma. This, researchers report in the May 10th issue of the Journal of Neuroscience, may block the progression of multiple sclerosis (MS)...."Our results suggest that stem cells engineered to be resistant to the harmful cytokines present in the extracellular milieu of the breached CNS of MS patients would stand a better chance of surviving and accomplishing remyelination," Dr. Popko concluded."

2006-05-26T08:35:00.000-07:00

Early multiple sclerosis treatment has 'remarkable' benefits - Starting drug therapy before a confirmed diagnosis of the nerve disease can delay its progression:
"...Usually, doctors don't start treatment until a person has had two separate attacks, but Dr. Mark Freedman of the University of Ottawa and his colleagues found they could delay the development of the disease by starting people on a drug called interferon beta-1b (brand name Betaseron) after just one episode of symptoms suggestive of MS. Freedman describes the treatment benefits as 'remarkable.'....The study involved 468 people who'd had just one MS-like attack, as well as at least two areas of nerve damage visible on a brain scan...."

2006-05-26T08:30:00.000-07:00

TorontoSun.com - Canada - Genetics link to MS disputed:
"Asad Wali jokes that he can't blame his parents anymore now that a new study shows MS may be caused by place of residence during childhood rather than ancestry..."

2006-05-26T08:25:00.000-07:00

Elan targets June for Tysabri future:
"Elan is hoping to clarify the future of its multiple sclerosis drug Tysabri by the end of June, it confirmed today. Speaking at the group's annual general meeting, Elan's Chief Executive Kelly Martin said he hoped that Elan would have a better idea about the controversial drug's future prospects by June 28. The company is hoping to get the goahead from regulators in June, allowing them to begin relaunching the drug in the third quarter...."

2006-05-26T07:27:00.000-07:00

HERO'S - PERSEVERANCE: Dad's MS spurred teen to launch research project & attend Harvard:
"Lev Shaket, 17, who will attend Harvard University this fall, began doing research on MS with scientists at Emory and Georgia State universities three years ago, after learning that his father had the disease...This fall he's heading to Harvard University. His scholarship includes free tuition. But all that's secondary to helping his father. "I just look at it in terms of positive side effects," he said of his father's illness. "That it launched my career and that it made me try to treat [MS] and cure it." The Shaket family includes 17-year-old Lev and parents Alexander and Janna. In 1990, they came to the United States from St. Petersburg (then Leningrad), Russia; Lev was 2 years old. When Lev was an eighth-grader, in 2000, Alexander Shaket was diagnosed with MS. He eventually stopped working at a paper mill.

Immediately after learning of his father's MS, Lev began reading voraciously online about the disease. Soon he was writing e-mails to neurological researchers at Emory, expressing his wish to do research with them. He left out the detail about his fatherYue Feng, an Emory professor with a doctorate in cellular biology, took him under her wing, first curious and then impressed by the ambitious 10th-grader. "He'd come in after 4 o'clock and stay as late as possible," she said."......"

2006-05-26T07:24:00.000-07:00

HERO'S - PERSEVERANCE: 'Gina's Giants' Raise Nearly $5,600 for MS

2006-05-26T07:22:00.000-07:00

MS Drug Trial Had Shortfalls, U.K. Probe Finds :
"Parexel International Corp., which ran a drug trial in London that left six men with multiple organ failure earlier this year, didn't have a doctor with adequate training screening the patients...."

2006-05-26T07:17:00.000-07:00

HERO'S - PERSEVERANCE: Former Miss America contestant 'puts it all in the Lord's hands'

2006-05-26T07:12:00.000-07:00

Patients Play Russian Roulette With Health to Pay for Medicines:
MS patients must play 'Russian roulette' with their health as financial pressures force them to gamble on which prescribed drugs to pay for and which to reject.

2006-05-26T07:08:00.000-07:00

HERO'S - PERSEVERANCE: "Slugger excels after overcoming adversity:
"Johanna Iwasaki can't help but laugh about it now. Playing her first full year on varsity, she is one of the best hitters in her school's lineup..."

2006-05-25T17:03:00.000-07:00

HealthTalk - MS - Treating MS: The Disease and Its Symptoms: "Hear how medications are improving, both to slow long-term progression of MS and manage day-to-day symptoms."
When: June 22, 2006 - 8:30 p.m. Eastern (5:30 p.m. Pacific)
Where: On the phone - On the Internet
George Hutton, M.D. - George Hutton, M.D.
[The site is owned by a Biogen/Avonex - it is very good]

2006-05-25T08:32:00.000-07:00

Recently Published Patent Application for detecting MS

2006-05-25T08:29:00.000-07:00

Recently Published Patent Application
The invention described in this patent application is a method for treating MS. The method includes giving a patient a combination of substances. The invention is combining CAMPATH with either REBIF, AVONEX, BETASETON, ROFERON, INTRON, PEG-INTRON, or COPAXONE, to treat multiple sclerosis. The patent application gives examples and models to detail that this combination is an effective treatment.

2006-05-25T08:18:00.000-07:00

DenverPost.com - Senate sitting on stem-cell act: "During the past year, more than 1.5 million people were diagnosed with diabetes, 55,000 were diagnosed with Parkinson's disease and roughly 8,700 were diagnosed with MS. Embryonic stem-cell research may hold the key to one day unlocking a cure for these and many other horrible diseases, but sadly that research has been stymied....."

2006-05-25T08:13:00.000-07:00

Tysabri: A RAISE IN IT'S PRICE?: "Chief Executive Kelly Martin said Thursday there is future 'headroom' to raise the price of MS drug Tysabri after its anticipated return to the market in the U.S. The U.S. Food & Drug Administration will make a final decision on Tysabri's re-entry by June 28, and most analysts see it back on the market in the U.S. inthe third quarter of 2006. 'Clearly there's headroom and a business legitimacy for one to raise the price,' Martin told a press briefing after the company's annual general meeting, adding the issue will be discussed with Elan's Tysabri partner Biogen Idec Inc...."

2006-05-24T20:49:00.000-07:00

WTOP: Doctor Who Gave NFL players Steroids loses license:
"Shortt also faces a state criminal investigation in the death of a woman who died three days after receiving intravenous hydrogen peroxide to help her MS...."

2006-05-24T20:46:00.000-07:00

Cannabinoid trial for progressive MS - MS Society of UK:
"CUPID stands for Cannabinoid Use in Progressive Inflammatory brain Disease. CUPID is a clinical trial which will evaluate whether THC, one of many chemical compounds (cannabinoids) found in the cannabis plant, might slow the development of disability in MS..."

2006-05-24T20:05:00.000-07:00

Aaron Solowoniuk of Billy Talent rocks on with MS
"Aaron Solowoniuk is the drummer of the hit band Billy Talent which is recognized around the world for their spirit, attitude and explosive rebel music. Aaron has been with the group from the beginning. He recently posted a letter to fans describing his experiences with MS - you can view the whole letter by clicking above.

"The first song on our first record is called "This Is How It Goes". It's a song about one of Ben's friends who has multiple sclerosis. Today I would like to let you know that I am that friend with MS.

It was November of 1997, I had just started a new job at Daimler Chrysler building the new Intrepid, Concorde and 300M. I was making more money, and I could take off more time to play shows with my band Pezz. Days after starting my new job I got a strange numbness in my legs. I couldn't walk for more than five minutes without having to sit down because of this pain in my legs. I thought it was just because this job was a lot more physically demanding then my last job.

After months of tests I was told that I probably had MS but a full diagnosis couldn't be made until I had another symptom within two years.

In November of 1998 the numbness in my legs was gone but I could make it come back by bending my neck forward. This would also send a feeling of an electrical shock to my feet. Just a couple months later in January of 1999, I suddenly got an awful pain in my left eye. It was like being punched in the eye by a ghost. I went straight to my eye doctor; he told me I had optic neuritis.

When I told this to my neurologist, I found out that it's very common for people with MS and the disease was progressing. He wanted me to start a new type of medicine. I had to self-inject myself three times a week in the arm, thigh, stomach or butt – and do this for the rest of my life.

I practically ran out of the doctor's office and into the stairwell with my girlfriend close behind me. We cried in the stairwell for a while and then went right over to my parents' house. Through all of this madness, I was so lucky to have my girlfriend, who is now my wife and the mother of our amazing daughter, beside me.

Coming to terms with the fact that I had to start giving myself needles forever was really hard. A couple of the side effects really hit me once I started the medication. I fell into a deep depression and started seeing a psychiatrist. I really felt like my life was falling apart. I had always wanted to be a drummer in a rock band but was told I should "take it easy". I remember saying "ya right" in my head: none of my dreams had come true and I now had an incurable disease.

It was really rough for the first year and a half but the new medicine started to work. The MS Society of Canada helped me get all the information and tools to get my life back on track. My symptoms were gone, and when they did come back they were just minor set backs.

We changed the name of the band from Pezz to Billy Talent and continued writing music. We released a four song EP and got a record deal. I quit my job and started playing drums full time.

After recording our first record it was time to go on tour. Our first record took us across Canada five times, America four times, Germany five times, the UK four times and a weekend in Japan. I've also met a lot of my musical heroes and even become friends with a couple of them.

I guess the reason I'm telling you this is because I didn't let something like MS get in the way of me becoming who I was suppose to become.

Please share this story with anyone you think it would help. There are a lot of people young and old that are fighting some sort of disease and thinking that they can't win. You really can win if you believe in yourself."

Aaron"

2006-05-24T19:59:00.000-07:00

News Release - "MS risk influenced by childhood environment - MS Society of Canada
Study of children and adults sheds new light on MS - The Multiple Sclerosis Society
of Canada announced findings from a Canadian study that shows the risk of MS may be influenced by place of residence during childhood rather than ancestry. The study results were published in a recent edition of Neuroepidemiology. The study puts into question the belief that MS is a disease targeted primarily at Caucasians or those with ancestral ties to areas north of the equator such as Northern Europe...."