TYSABRI-The New England Journal of Medicine -3/2/06-Editorial- Selective Treatment of MS -CLICK HERE"Natalizumab, a recombinant monoclonal antibody against 4 integrins, is the first selective immunomodulating drug for the treatment of multiple sclerosis and, by several criteria, is an advance over current therapies. The antibody was developed to block the adhesion of activated T cells to endothelial cells and thereby reduce the inflammatory feature of the multiple sclerosis plaque. Parenthetically, this advance attests to the value of translational research in a disease for which there is only partial knowledge of the mechanism. Natalizumab has also evinced interest for the treatment of Crohn's disease and rheumatoid arthritis but with less certain results in limited . . . [Full Text of this Article]"