[ABSTRACT] "Functional MRI and MS: "There is increasing evidence that the severity of the clinical manifestations of multiple sclerosis (MS) does not result simply from the extent of tissue destruction, rather it represents a complex balance between tissue damage, tissue repair and cortical reorganization. Functional magnetic resonance imaging provides information regarding the extent and nature of brain plasticity following MS-related structural injury, with the potential to limit the clinical manifestations of the disease."