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August 28, 2005
Possible Test May Help Diagnosis MS Early
A More Sensitive Diagnostic Test
A team of medical researchers headed by neurologist Luisa Villar, MD, at the Hospital Ramon y Cajal in Madrid, Spain, wrote in the journal Archives of Neurology that they recently developed a new, more sensitive, diagnostic test to detect levels of IgG in the cerebrospinal fluid of people suspected of having MS. This test "in conjunction with magnetic resonance imaging, can help in the early diagnosis of MS," the study investigators wrote. The aim of this research, therefore, was to determine the efficacy of the test in a group of people diagnosed with various neurologic disorders.
Three-hundred eighty five patients being evaluated in a hospital neurology department were recruited into this observational study. Each patient underwent the OCGB test to search for levels of IgG.
Few False Positives/False Negatives
At the end of the study, Villar and her colleagues found the test was positive for IgG in 127 patients with MS, a 96% sensitivity. The antibody was also found in just over a third of patients with central nervous system infections, and in one patient with motor neuron disease, the investigators reported. There were two patterns uncovered by the test that detected levels of IgG; one pattern showed IgG only in cerebrospinal fluid, which was found predominately in people with MS. The second pattern was found in both cerebrospinal fluid and in blood samples, which was more common in people with central nervous system infections, Villar's group noted.
In all, the test was more than 96% sensitive and had a specificity of over 92%, the researchers reported. When they considered the value of the test in only the MS patients, the study investigators found it still provided 96% sensitivity and more than 99% specificity. Sensitivity represents the probability of a screening test to correctly diagnose a disease. By contrast, specificity represents the ability of such a test to rule out a disease in a patient.
"The accuracy of this OCGB method reinforces the value of cerebrospinal fluid studies in the differential diagnosis of MS," wrote Villar and her colleagues.MS Neighborhood : CLICK
A team of medical researchers headed by neurologist Luisa Villar, MD, at the Hospital Ramon y Cajal in Madrid, Spain, wrote in the journal Archives of Neurology that they recently developed a new, more sensitive, diagnostic test to detect levels of IgG in the cerebrospinal fluid of people suspected of having MS. This test "in conjunction with magnetic resonance imaging, can help in the early diagnosis of MS," the study investigators wrote. The aim of this research, therefore, was to determine the efficacy of the test in a group of people diagnosed with various neurologic disorders.
Three-hundred eighty five patients being evaluated in a hospital neurology department were recruited into this observational study. Each patient underwent the OCGB test to search for levels of IgG.
Few False Positives/False Negatives
At the end of the study, Villar and her colleagues found the test was positive for IgG in 127 patients with MS, a 96% sensitivity. The antibody was also found in just over a third of patients with central nervous system infections, and in one patient with motor neuron disease, the investigators reported. There were two patterns uncovered by the test that detected levels of IgG; one pattern showed IgG only in cerebrospinal fluid, which was found predominately in people with MS. The second pattern was found in both cerebrospinal fluid and in blood samples, which was more common in people with central nervous system infections, Villar's group noted.
In all, the test was more than 96% sensitive and had a specificity of over 92%, the researchers reported. When they considered the value of the test in only the MS patients, the study investigators found it still provided 96% sensitivity and more than 99% specificity. Sensitivity represents the probability of a screening test to correctly diagnose a disease. By contrast, specificity represents the ability of such a test to rule out a disease in a patient.
"The accuracy of this OCGB method reinforces the value of cerebrospinal fluid studies in the differential diagnosis of MS," wrote Villar and her colleagues.MS Neighborhood : CLICK